Welcome, Laboratory for Infectious & Tropical Diseases (LITD)
We study malaria parasites. Malaria remains a leading cause of childhood illness and death in sub-Saharan Africa, threatening the health and economic well-being of families across the region, including in Ghana. Effective vaccines and alternative drug candidates are still lacking, largely because our understanding of the biology and immunology of the parasite's transmission stages remains limited- closing that gap is the central focus of our research programme.
We have established field sites for malaria research in the Ashanti, Volta and Northern Regions, where we apply modern molecular and immunological approaches to understand fundamental Plasmodium falciparum biology within the human host- how the parasite develops, how hosts respond to infection, how host immunity and the parasite interact, and how gametocyte biology and immunity play out in infected populations. We work collaboratively with national and international partners across academia, industry, health delivery and policy to advance our research and support the development of new drugs and vaccines against malaria.
Our laboratory is based in the Department of Clinical Microbiology, School of Medical Sciences, at the Kwame Nkrumah University of Science and Technology, Kumasi, and is part of the West African Centre for Cell Biology of Infectious Pathogens at the University of Ghana, Legon, Accra. We also collaborate with a number of national and international partners across the USA, Europe and Australia.
Research
Gametocyte sex ratio determination and variant antigen expression
Malaria parasites must sense their environment to regulate gene expression- for instance
Read MoreAntibody and cellular immune responses to Plasmodium falciparum gametocytes
The current drug of choice for acute malaria is artemisinin-based combination therapies (ACTs).
Read MoreEstablishing CRISPR-Cas9 gene editing of malaria parasites
To move beyond correlational studies and directly test gene function, we are establishing
Read MoreMalaria parasite adaptations in human tissues and whole parasite vaccines
P. falciparum gametocytes- the parasite's transmission stage- develop while sequestered in
Read MoreAntibody and cellular immune responses to gametocytes
The current drug of choice for acute malaria is Artemisinin-based combination therapies (ACTs).
Read MoreBone marrow malaria– understanding and preventing gametocyte sequestration and retention
Gametocytes of P. falciparum go through several forms of development in different sites of the human body.
Read MoreVacancies available
Open Training Sessions
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